An explosion at a chemical plant in Mississippi caused an ammonia leak and prompted evacuations. “At this time Numerous emergency and hazmat crews are currently on the scene in Yazoo City, Mississippi, after a massive explosion at the CF Industries chemical plant involving anhydrous ammonia. Residents have been evacuated as thick orange toxic clouds rise over the area, and all residents of Yazoo City are being urged to shelter in place,” Rawsalerts wrote. “The Mississippi Emergency Management Agency is also advising those near the affected zones to leave their homes immediately while crews work to contain the situation. The cause of the explosion is currently under investigation,” the post added. #BREAKING: A massive hazardous explosion has taken place at a chemical plant involving anhydrous ammonia Residents have been evacuated⁰⁰#YazooCity | #Mississippi⁰⁰At this time Numerous emergency and hazmat crews are currently on the scene in Yazoo City, Mississippi, after… pic.twitter.com/19ADaVyY6L — R A W S A L E R T S (@rawsalerts) November 6, 2025 Fox News has more: The governor urged people near Renshaw Road and Generette Road to evacuate immediately and advised those in the surrounding area to shelter in place. The American Red Cross opened a reception center in the city to support affected residents. The state’s Department of Transportation said lanes on U.S. Highway 49 were blocked in both directions. The Mississippi Department of Environmental Quality said “air monitoring operations are underway and will continue as long as necessary to ensure public safety.” “Thank you to all of Mississippi’s first responders and emergency managers for quickly responding to the leak,” the governor said. CF Industries manufactures ammonia, most often used as fertilizer, and its Yazoo City facility has a gross annual capacity of 570,000 tons of ammonia, according to the company. “The state of Mississippi has not received any reports of injuries or deaths. MDEQ is on site and actively monitoring air quality. Initial results were 25 PPM, which allowed rail traffic to begin. The shelter-in-place order has not been lifted and will remain in effect until air monitor readings begin trending downward,” Mississippi Gov. Tate Reeves said. “Traffic control points have been established on U.S. 49 to divert traffic. This will continue until MDEQ and CF Industries give Yazoo County the all-clear. The American Red Cross has set up a reception center at Yazoo County High School’s gymnasium. At this time, no one has checked in. Besides the state agency personnel who are responding to leak, the state of Mississippi has not received any additional requests for resources,” he added. Update on the chemical leak at CF Industries’ plant north of Yazoo City: The state of Mississippi has not received any reports of injuries or deaths. MDEQ is on site and actively monitoring air quality. Initial results were 25 PPM, which allowed rail traffic to begin. The… — Governor Tate Reeves (@tatereeves) November 6, 2025 In an update Thursday morning, Reeves said the “shelter-in-place order and traffic controls have been lifted.” Update: The shelter-in-place order and traffic controls have been lifted. https://t.co/AnREEtgnK3 — Governor Tate Reeves (@tatereeves) November 6, 2025 ABC News noted: The facility is able to store about 48,000 tons of ammonia, although the exact amount there when the explosion took place was not immediately clear. CF Industries said in a statement that there are no injuries, and “all employees and contractors on site at the time of the incident have been safely accounted for.” Andre Robinson, who lives about a half-mile (800 meters) from the facility, said he and his son were getting ready to make gumbo when he heard what sounded like a sonic boom or a tree crashing on his house. “There was a boom and then the house shook,” he said. When he looked outside, Robinson said he saw smoke rising from the facility and started to smell a strong scent of ammonia. “We’re used to the ammonia smell, but not that bad,” he said, adding that his family has since evacuated to Jackson.