How can microorganism communities known as biofilms, and have been hypothesized to be responsible for early life on Earth, be used for space exploration? This is what a recent study published in npj Biofilms and Microbiomes hopes to address as an international collaboration of researchers investigated the pros and cons of using biofilms in spaceflight. This study has the potential for scientists to better understand the role of biofilms in spaceflight while mitigating health risks of astronauts.