They do move in herds.

It’s not good news, but it also not yet terrible news.

Twenty-nine state attorneys general went into an Oakland, California courtroom this month seeking roughly $200 billion from Meta over claims of teen addiction. Their case ended in its second week, with a settlement agreement that requires Meta to pay up to $17 billion across 10 years and make several product changes, such as a midnight-to-6 a.m. blackout, a two-hour daily cap, and an optional chronological feed. While some of these requirements are steps in the right direction, the settlement gives the company too many ways to avoid making meaningful, lasting changes to their products. The agreement is time-limited, relies on Meta's definitions of critical terms, and doesn't require detailed disclosure to the public.What makes this settlement worthy of attention is the deal's requirement for an independent auditor, which is the first time anyone examining Meta's product design will be chosen by someone other than the company. Independent regulators, such as the Federal Communications Commission, are a proven (if imperfect) way to protect the public interest, and social media platforms are now at least as important to our lives (and our children's lives) as the broadcast and telecom industries that the FCC regulates.Under the agreement, an independent auditor will have access to Meta's internal data and engineers, a mandate to report annually on whether the company is doing what it promised, and an obligation to make a summary of each report public. On the surface, this is good news. But look a little deeper and it becomes clear the auditor's power is too limited. First, the agreement repeatedly defers to Meta's current business practices, rather than defining new standards based on the public interest. For example, Age Appropriate Experiences are defined as "content captured in Meta's applicable Ages 13+ content setting." Harmful Experiences are defined as "behaviors that violate Meta's Community Standards," and age verification data must only be protected "using Meta's highest data privacy and security standards." This creates myriad openings for clever Meta employees to meet the letter of the agreement while avoiding real change.Second, the auditor's public report will be heavily redacted. The summary will describe the status of Meta's implementation of the agreement for the period, and whether Meta adopted or agreed to adopt the auditor's recommendations. But it allows Meta to exclude information that it deems "nonpublic, proprietary, or Confidential." Given that one of the core issues of this case was Meta burying unfavorable data, this is deeply concerning.This limited public disclosure is insufficient for external researchers and the public interest. Meta says in its public announcement of the settlement that the agreement includes the establishment of "an independent social media research foundation" with which "Meta will share consented user data… to advance independent research into teen well-being" — but we could find no mention of this foundation as an obligation in the settlement. Finally, the requirement for an independent auditor expires in as little as five years (the agreement itself expires after 10 years). This creates an incentive for Meta to run down the clock until it can return to business as usual, rather than making permanent changes.We do not mean to suggest this agreement is not a positive step. Its weaknesses are not failures of negotiation, but rather a reflection of the limits of a legal settlement: a bargain with one company, for a fixed period, based on specific legal claims at the time of agreement.That's why legislators urgently need to act now. A new law, preferably at the federal level, should convert the independent auditor into a strong, permanent regulatory oversight body, funded with annual fees on big tech companies in proportion to the size of their business and impact on society.A permanent regulator could also go beyond one-time agreements on specific Meta features, and build an ongoing body of research and practice around safety best practices. This would allow society to develop its own definitions and standard of care that could apply internet-wide. A more comprehensive approach to regulating social media, looking beyond issues of child safety on specific platforms, is needed.We do not mean to suggest this agreement is not a positive step. Its weaknesses are not failures of negotiation, but rather a reflection of the limits of a legal settlement: a bargain with one company, for a fixed period, based on specific legal claims at the time of agreement.There's a particular need for the public to have more insight and control over how social media feeds are constructed. The agreement requires Meta to offer teens the option of choosing a non-personalized (and thus presumably less addictive) "home" feed, but doesn’t make this the default, and still lets teens continue to use the personalized feed. Since research has shown most people dislike chronological feeds, this requirement will probably have limited real-world impact. Related stories'There's a sense that these algorithms are objective and they get to know you': How social media warps our understanding of healthcareBefore we ban kids from social media completely, here's what we should try firstNext-generation AI 'swarms' will invade social media by mimicking human behavior and harassing real users, researchers warnFurther, the provisions establish that the non-personalized feed will consist of "content [that] is populated by accounts the Teen User follows or has friended, displayed in chronological order." This assumes that a chronological feed is the best alternative to Meta's curated feed. There is an argument that well-designed algorithms could actually contribute to improved mental health if optimized to deprioritize toxic posts and misinformation, while aligning with users' preferences as to what gives them long-term value. We also urgently need independent, rigorous audit standards for privacy and security of online identity data. Trusting the same company that gave us the Cambridge Analytica scandal to grade their own homework on this front is a bad bet.We hope that this settlement agreement will become a baseline, not a high water mark, for more thoughtful regulation of internet platforms. This case, and the many other pending lawsuits in state and federal courts, are useful in providing evidentiary material, political attention, and specific concessions. But they are not substitutes for the durable rules and institutions that only Congress and state legislatures can provide. Editor's Note: This opinion piece was jointly published on Friday Aug. 28 in Jonathan Bellack's free weekly newsletter, Platformocracy, which advocates for more democracy in our online lives.This article is for informational purposes only and is not meant to offer medical advice.Opinion on Live Science gives you insight on the most important issues in science that affect you and the world around you today, written by experts and leading scientists in their field.

There are many theories as to how the diabetes drug metformin lowers blood sugar levels, but now, scientists think they've discovered the main route.It turns out that the drug, primarily used in type 2 diabetes, forces gut cells to absorb and burn extra glucose. It achieves this by messing with gut cells' mitochondria — their internal power generators.Although metformin was first used in patients in the 1990s, scientists have been unsure of how it works. "Every year there's a new mechanism for metformin that says last year's mechanism was wrong," said study co-author Navdeep Chandel, a biochemist at Northwestern University.Part of the problem is that metformin affects several organs. "Metformin has a complex mechanism of action, with effects in several organs and on different aspects of metabolism, making it difficult to identify a single mechanism that explains all of its effects," Manuel Vázquez Carrera, a pharmacology researcher at the Sant Joan de Déu Research Institute who was not involved with the study, told Live Science in an email.Some studies suggested that metformin causes intestinal cells to use up glucose, and an animal study released last year proposed that the drug causes glucose to move from the bloodstream into the intestines, where gut bacteria can then break it down. Other research pointed to the liver, proposing that the drug lowers blood glucose levels by inhibiting gluconeogenesis, a process in which the liver makes glucose from other molecules, usually to regulate sugar levels during fasting or exercise. The scientists exploring the drug's action in the liver found that metformin interacts with a large complex of proteins inside mitochondria. Called mitochondrial complex I, it's a key player in generating cells' primary energy currency: the molecule adenosine triphosphate (ATP).The new study suggests that metformin changes the activity of mitochondria (pictured) inside intestinal cells in a way that ultimately causes them to burn more sugar. (Image credit: MARK GARLICK/SCIENCE PHOTO LIBRARY via Getty Images)However, the theory that metformin mainly works by targeting this complex was quickly dismissed. That's because the drug's concentration in the liver is too low to exert an effect, Vázquez Carrera said.But elsewhere in the body, it's a different story. In the recent study, published in May in the journal Nature Metabolism, Chandel and his colleagues found that metformin does work by targeting mitochondrial complex I — but it does so not in the liver but in the intestines, where the drug builds up to higher concentrations.Their first clue came when they compared metabolites in the bloodstreams of people taking metformin and those unexposed to the drug. For one metabolite, called citrulline, they saw the biggest drop in concentration following a dose of metformin. This blood metabolite is produced almost exclusively by mitochondria in intestinal cells, revealing that the drug affects gut mitochondria.In further experiments, the team genetically modified mice so they had a backup for complex I in the intestines. The backup was a different enzyme that performs a similar function but is not affected by metformin. That meant that if the drug works by inhibiting complex I, mice equipped with backups could bypass the drug's effects. When the researchers administered metformin to these mice, they found that the drug was much less effective at lowering citrulline levels in the blood, suggesting that metformin acts on complex I in intestinal cells. Besides affecting citrulline, the genetic tweak also reduced metformin's effects on blood sugar by 80%, Chandel said. This means inhibition of complex I is probably the main mechanism behind the acute effects of the drug, he added.Mitochondria can generate roughly 30 ATP molecules from one glucose molecule, but when these powerhouses are blocked, the cell tries to compensate by running a less-efficient ATP production line. This alternate pathway, called glycolysis, generates only two ATP molecules per glucose molecule. The researchers argued that by inhibiting intestinal mitochondria, metformin might force the cells to sequester and burn through as much glucose as possible with this less-efficient strategy. In turn, that lowers blood sugar levels. Related storiesNew drug could prevent diabetes complications not fixed with blood sugar control, study hintsWhat is type 5 diabetes? Newly recognized form of the disease gets nameDiabetes rates are lower in high-altitude environments —‬ and scientists may have discovered whyThey were able to show this in lab mice. Metformin caused glucose to accumulate in intestinal cells of normal mice, not the mice carrying backup enzymes, suggesting that the cells with blocked-up mitochondria usurp hoards of glucose to run glycolysis instead."Much of the mechanistic evidence comes from male mice, so it remains unclear how well the findings translate to humans and whether there are sex-specific effects," Vázquez Carrera noted.Most of metformin's sugar-lowering activity — about 80% — involved complex I, but it's likely that the drug has additional targets. In future work, Chandel and his colleagues aim to explore how the drug affects other aspects of the body's biology, such as the liver or the gut microbiome.This article is for informational purposes only and is not meant to offer medical advice.

The Atacama receives an average of 15 millimeters of precipitation per year, but in August, some areas received 40 millimeters in just a few days.