A new report identifies searching for life as the top science priority for humanity's first landing on Mars, ranking it above understanding water cycles, mapping geology, or even studying how the Martian environment affects astronaut health. The report outlines four possible exploration campaigns, with the highest ranked approach calling for missions totalling 330 sols at a single scientifically rich site where crews could investigate everything from ancient lava flows to active dust storms. By placing the search for extraterrestrial life at the centre of human Mars exploration, the report reimagines the first crewed mission not just as a milestone for spaceflight but as humanity's best chance to answer whether we're alone in the universe.