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Researchers reveal dual-function mechanism of bacteriophage-derived protein AcrIIA15
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Researchers reveal dual-function mechanism of bacteriophage-derived protein AcrIIA15

In response to the efficient attacks of the host CRISPR-Cas system‚ bacteriophages have evolved various resistance strategies‚ including encoding anti-CRISPR (Acr) proteins. Since their initial discovery in 2013‚ over a hundred Acr proteins have been identified. These proteins use different mechanisms to inhibit the recognition and cleavage of target nucleic acids by the Cas protein-RNA complex‚ and have great potential for development as gene editing regulatory elements.
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