President Trump departs Kuala Lumpur, Malaysia, en route to Tokyo, Japan.

Michael Savage explained on his Newsmax show why he wants Andrew Cuomo to win the New York City mayoral race next month. Andrew Cuomo has many faults and we have shown him no mercy on the Sentinel but he was good with the New York budget. Curtis Sliwa has never run anything, including a budget, […] The post Michael Savage Takes on the NYC Mayoral Race with the Commie Islamist appeared first on www.independentsentinel.com.

BY THE OPTIMIST DAILY EDITORIAL TEAM For children born with ADA-SCID, a rare genetic disease that severely compromises the immune system, everyday germs can be fatal. ADA-SCID (short for severe combined immunodeficiency due to adenosine deaminase deficiency) leaves the body unable to fight off infections. Untreated, many children do not survive past age two. A life-threatening diagnosis, a life-saving breakthrough But hope has arrived in the form of an ingenious gene therapy. In a study recently published in The New England Journal of Medicine, an experimental treatment saved the lives of 62 children diagnosed with ADA-SCID. The therapy, administered in just a single dose, has shown a remarkable 100 percent survival rate in patients followed for more than a decade. Among them is Eliana Nachem, who received the therapy ten years ago. Her father, Jeff, recalls how their family had to isolate completely to protect her. “My wife didn’t leave the house, I had to shower and change clothes before I could even hold Eliana,” he shared. Now, Eliana is thriving: she plays basketball, sings in the school choir, and is thriving at school. “It’s incredible,” Jeff said. How the therapy works The therapy works by extracting blood stem cells from a child, inserting a healthy copy of the faulty ADA gene using a lentivirus, and reinfusing the modified cells into the body. This treatment gives these isolated children a working immune system, and the chance at a liberated childhood. “To me, cure means a lifelong absence of disease,” said Dr. Donald Kohn of UCLA, who led the research. “We can’t say that definitively yet, but the clinical benefits have remained stable over 7 to 12 years.” Unlike earlier treatments such as weekly enzyme injections or risky bone marrow transplants, this approach may offer a safer and more lasting solution. Kohn’s team has also improved the process by freezing the altered cells, allowing treatments to be shipped and administered globally, offering an important step toward broader access. Cost, access, and the challenge of rare diseases Despite its promise, the therapy comes with a hefty price tag—up to one million euros per treatment. While the cost is steep, Dr. Kohn noted that current enzyme therapies are also expensive and must be continued for years. “So within a few years after the ‘one and done’ gene therapy, the overall costs should be less,” he said. Similar gene therapies, like Strimvelis, have also shown strong results but struggled with commercialization. Developed in Milan and approved in 2016, Strimvelis was eventually dropped by its pharmaceutical backers due to financial challenges. The Telethon Foundation now maintains its availability. Safety remains a concern, too. One child treated with Strimvelis developed leukemia from unintended DNA changes. The new therapy, however, uses lentiviruses rather than retroviruses and has not shown such side effects to date. Juan Antonio Bueren of CIEMAT in Madrid praised the results but cautioned about cost barriers. “There is a problem with commercializing gene therapies for rare diseases,” he said. “They require extensive production and long-term monitoring, making them very expensive.” A path forward for future therapies Though commercialization has stalled in the past, momentum is building. Kohn and colleagues founded a company, Rarity PBC, to bring the therapy to more families. With a $14.7 million grant from the California Institute for Regenerative Medicine, they are developing scalable production methods. So far, lentivirus-based therapies have shown potential in treating around 15 rare diseases. But as Bueren notes, pricing models remain a challenge, especially in public health systems across Europe. Despite these hurdles, families and researchers alike remain hopeful. “I don’t know what’s fair to charge,” said Jeff Nachem, “but this kind of treatment shouldn’t be denied to a small child who needs it to survive.” This latest success is more than a medical milestone; it’s a testament to what’s possible when science, persistence, and compassion converge. For dozens of children once confined to sterile rooms and a life of fear, it’s not just a treatment. It’s the freedom to live. Source study: The New England Journal of Medicine—Long-term safety and efficacy of gene therapy for adenosine deaminase deficiencyThe post A one-time gene therapy is helping kids beat a deadly immune disease first appeared on The Optimist Daily: Making Solutions the News.

BY THE OPTIMIST DAILY EDITORIAL TEAM As the temperatures drop, mice are on the move, looking for a warm, cozy place to call home. If you’ve spotted signs of these uninvited guests, such as chewed food boxes, droppings, or the pitter-patter of tiny feet, don’t panic. Understanding how mice get inside and what draws them to your space can go a long way in keeping your home rodent-free. 1. Small gaps and hidden holes Mice are masters of squeezing through impossibly tiny openings. Just a quarter-inch wide is enough for their bodies to wiggle through. Their sharp teeth make the problem worse, allowing them to chew through wood, insulation, and drywall to create new entrances. Do a walk-around inspection of your home’s exterior. Pay special attention to cracks in your foundation, holes beneath decks, and areas where pipes or cables enter. Seal gaps with steel wool and caulk or use hardware cloth for larger openings. 2. Doors, windows, and pet entries Loose door sweeps, misaligned weatherstripping, and even pet doors give mice a red carpet welcome. They’re also excellent climbers, capable of scaling brick, trellises, and even trees to reach open upper windows. Check for air drafts near windows and under doors. If air can escape, mice can enter. Replace worn-out seals and consider installing rodent-proof door sweeps. 3. Plumbing and drains It’s rare, but mice have been known to wriggle through drainpipes and emerge from toilets or sinks. Though they dislike water, desperate rodents will use this route if other access points are blocked. Inspect your drain system for cracks, broken joints, or poor seals. Cover floor drains with metal screens, and keep toilet lids closed in basements or unused bathrooms. 4. Roofs and attic vents To a mouse, your roof is a welcome mat. They’ll scale gutters, shimmy along wires, and leap from trees to reach attic vents or chimney flues. Once inside, they make nests in insulation and chew through wires and wood. Install wire mesh over vents, chimney openings, and downspouts. Trim tree branches back at least six feet from the roof to make jumping more difficult. 5. Stored items and secondhand furniture That old couch in the garage? Prime mouse real estate. Rodents love nesting in cardboard boxes, mattresses, and upholstered furniture, especially when stored in quiet corners of basements or sheds. Before bringing anything from storage into your home, inspect it carefully. When possible, use sealed plastic bins instead of cardboard boxes. Why mice move in: common attractants Easy-access food Mice can survive on just a tenth of an ounce of food per day, and on top o f that they’re not picky. Grains, sweets, pet food, and even crumbs are fair game. They also chew through paper and plastic packaging with ease. Store food (including pet treats) in airtight containers made of glass, metal, or heavy-duty plastic. Clean up spills right away, and take the trash out regularly. Warmth and shelter Mice migrate indoors as the temperature drops, especially into homes with central heating, cluttered spaces, or cozy hiding spots like wall voids. They’re also drawn to the warmth of appliances such as ovens, dryers, and water heaters. Declutter storage areas, seal access to wall cavities, and check behind appliances regularly. Water and moisture Though most mice get moisture from food, they won’t turn down a sip from a pet water bowl or a leaky tap. They’re also drawn to condensation on windows and damp areas like basements. Fix leaks, use dehumidifiers if needed, and empty standing water from plant trays or drip pans. Lush gardens A thriving vegetable patch or fruit tree can be a rodent buffet. Gardens offer both food and shelter, especially if overgrown or close to the house. Install rodent-proof fencing and store compost securely. Clear weeds and fallen fruit to reduce hiding spots.The post How to mouse-proof your home this fall: 5 entry points to seal and what attracts them first appeared on The Optimist Daily: Making Solutions the News.

LSU has made the move to fire their head coach Brian Kelly

News It: Welcome to Derry IT: Welcome to Derry Co-Creators Explain That Shocking Episode 1 Ending Yep, that just happened. And Andy and Barbara Muschietti tell us the genesis of that decision. By Vanessa Armstrong | Published on October 26, 2025 Credit: Brooke Palmer/HBO Comment 0 Share New Share Credit: Brooke Palmer/HBO Warning! This post contains major spoilers for the first episode of IT: Welcome to Derry! If you haven’t watched it yet and plan to, bookmark this post and come back to it after you’ve finished watching and picked your jaw up off the floor! If you’ve watched the first episode of HBO’s IT: Welcome to Derry, you’ve been on quite the roller coaster ride. After that unsettling cold open, the show ends in an equally visceral way. Characters we thought we’d be spending a bunch of time with are definitely totally dead (and in pieces). It was a bold move by the writers, and an idea that was there from the start. In a panel that Reactor attended, series co-creators, siblings Andy Muschietti and Barbara Muschietti, explained how the decision to kill off kids that viewers have already become attached to became part of the story. Andy started off by saying the idea appeared in the writers’ first few meetings, though Barbara clarified that it was the first day. “First day? It was me, Barb, Jason [Fuchs], Brad [Kane], and Cord Jefferson,” explained Andy, “and someone said, ‘Why don’t we kill them all?’” Credit: Brooke Palmer/HBO That someone was writer Brad Kane, though Barbara clarified that he only wanted to kill all the adults, not the kids. “I think that Brad was responding probably to the ongoing desire to shock the audience at the beginning, just to set up the table, to give people a sense that nothing here is sacred, nothing here is safe from this evil. So that will keep you at the edge of your seat for the rest of the show, because no one is safe,” said Andy. Pulling out the rug like that was shocking, but something Andy felt was necessary. “We felt like it was a subversion that this new story needed, as part of the innovations that we wanted to bring—the raise of the volume, of intensity, that we wanted to take this story to, and this show to.” Andy took a big breath and added, “Let’s see, it’s an experiment, really, because I haven’t seen it before. I mean, we all saw, like, the Red Wedding and things, where the characters that we’re putting all our hopes on, just suddenly are massacred and disappearing. And I was like, ‘Okay, now what?’ Obviously the game here is, ‘Here’s the new Losers. Let’s fall in love with them so we can go across the journey.’ And the subversion is quite there to basically tell the audience nothing is safe, but also weird things will happen in this show, and there’s unpredictability.” New episodes of IT: Welcome to Derry premiere on HBO on Sundays. [end-mark] The post <i>IT: Welcome to Derry</i> Co-Creators Explain That Shocking Episode 1 Ending appeared first on Reactor.

Schumer’s Shutdown Starvation Spectacle: 40 Million Americans Face Famine—Nice One, Dems

Military paychecks are again at risk as the stopgap $8 billion President Donald Trump redirected to cover troops' salaries during the government shutdown is projected to run out by Oct. 31 - leaving Congress with little time...