Treatment for depression has historically taken a “one-size-fits-all” approach, but this may be about to change as new research has found six kinds of depression that are identifiable through brain scans. The different kinds, or “biotypes”, respond better to some treatments than others, and could aid us in delivering more effective care for people living with depression, and faster.The study looked at the functional MRI (fMRI) scans of 801 participants who had been previously diagnosed with anxiety or depression. They looked at their brain activity both while at rest and during a series of cognitive and emotional function tests, paying special attention to which regions of the brain were active and looking for connections between them. With the help of machine learning, they were able to cluster the scan results based on similarities and identified six distinct patterns of brain activity.The team then randomly assigned one of three common antidepressants or behavioral talk therapy to 250 of the participants and assessed how they responded to the treatment. It revealed patterns in the different subtypes of depression, referred to as biotypes, and the treatment approach that was most effective.The goal of our work is figuring out how we can get it right the first time.Dr Leanne WilliamsFor example, Venlafaxine, sometimes known as Effexor, proved to be the most effective medication for a biotype that was notable for overactivity in certain regions of the brain. Another biotype characterized by high levels of activity in three regions of the brain associated with problem solving and depression was found to respond best to behavioral talk therapy.“To our knowledge, this is the first time we’ve been able to demonstrate that depression can be explained by different disruptions to the functioning of the brain,” said senior study author Dr Leanne Williams in a statement. “In essence, it’s a demonstration of a personalized medicine approach for mental health based on objective measures of brain function.”Williams, the inaugural Vincent VC Woo Professor of Psychiatry and Behavioral Sciences, is a professor of psychiatry and behavioral sciences and the director of Stanford Medicine’s Center for Precision Mental Health and Wellness. She lost her partner to depression in 2015, and has focused her work on pioneering the field of precision psychiatry that centers around individualizing diagnosis and using a personal approach to tailor treatment.Around a third of people with depression have treatment-resistant depression, which means despite multiple rounds of medication and talking therapy, their symptoms don’t improve.  It’s hoped that by taking a more precise and personalized approach to depression management, physicians can better help patients to fully reverse their symptoms to healthy levels.  “The goal of our work is figuring out how we can get it right the first time,” Williams said. “It’s very frustrating to be in the field of depression and not have a better alternative to this one-size-fits-all approach.”The study is published in the journal Nature Medicine.

Saying "the day after tomorrow" when making arrangements is on par in terms of annoyance as having to say the second cous in cous cous. If only there was a simpler way to convey you are talking about the day after tomorrow without having to say such a mouthful.Well good news, because there is a word for that, it has just fallen out of use in recent years. People on the Internet have recently rediscovered the word, and are hoping to bring it back.     IFLScience is not responsible for content shared from external sites.That word is "overmorrow", coming from "over" (above) and the old English word for morning (morrow). The first documented use of "overmorrow" comes from a version of the Bible produced in 1535, spelled then as "ouermorow"."Then spake Tobias unto the virgin, and said: Up Sara, let us make our prayer unto God today, tomorrow, and overmorrow," a modern-day translation of the text reads. "For these three nights will we reconcile ourselves with God, and when the third holy night is past, we shall join together in the duty of marriage."This version of the Bible –  the Coverdale Bible, the first English translation of the Bible to contain both old and new testaments – also contains another archaic term for the day before yesterday which could be a real timesaver."And Iacob behelde Labans countenaunce, & beholde, it was not towarde him as yesterdaye and yeryesterdaye," the text reads, "but the God of my father hath bene with me"."Overmorrow" fell out of common use pretty quickly, before the end of the 16th Century, with people for some reason preferring to use four words instead of one. However, it cropped up in the UK Parliament as late as 1925, when Sir W. Joynson-Hicks said "we can go not overmorrow, but on Thursday" during one debate.In German, the word "übermorgen" is used for the day after tomorrow, while French uses "surlendemain" for the same concept. Perhaps, as the Internet seems keen, it is time to bring back these time-saving words. And then we can move on to that irritating second cous.

Broadway stars and celebrity elites gave failed Democratic presidential nominee Hillary Clinton a standing ovation at the 77th Tony Awards that aired live on CBS on Sunday night at the David H. Koch Theater at Lincoln Center.  Dressed in an intricate muumuu, Clinton appeared as one of the producers of a Shaina Taub musical called “Suffs,” which is about the “1913 women’s movement,” according to the show’s synopsis. Who would have thunk that the Clinton had an artistic side to her? Clinton went on to stress ‘how important it is to vote,” this without any verbal recommendations on who to vote for. Oddly enough, she didn’t utter the words, Joe or Biden. Hillary Clinton: Thank you, and what an evening. [Applause continues] Now, I have stood on a lot of stages, but this is very special. I know a little bit about how hard it is to make change... So I am extremely proud of this original American musical by Shaina Taub, now a two-time Tony winner. [Applause] And, of course, it is about some American originals. The suffragists who fought so valiantly for so long to give women in our country the right to vote. It is almost impossible to think about what a challenge that was, but now it is an election year, and we need to be reminded about how important it is to vote. So please welcome the company of ....  In fact, President Joe Biden wasn’t mentioned one time by name thoughtout the whole awards show by anyone. Another topic the Broadway stars completely avoided was the Israel-Hamas war, which is surprising considering how politically vocal some of these stars have been in the past on various issues. Not one person had the guts to condemn the atrocities committed by Hamas or even the alarming rise of anti-semitism in the U.S. — instead the audience and viewers at home were pummeled with identity politics and the LGBTQ agenda.  For example, male dancers frolicked around on stage and kissed passionately during one the performances by the dance-musical “Illinoise,” which took home the Tony Award for Best Choreography. The Tony Awards has been struggling to attract viewers for many years now. It should come as no surprise, as many everyday Americans are clearly tired of the lectures from the liberal elite, divisiveness, the focus on skin color and sex. 

First, they lost the comedians. They let the politics get in the way of the funny. You never do that. The late-night shows became sappy appeals. Comedy Central would play half an hour of an Englishman explaining how stupid we all are in America. “Clapter” replaced laughter. The message became the point. And funny men like Shane Gillis, Bill Burr, and Dave Chappelle rebelled. But progressive politics are getting in the way of a whole lot more these days. Public safety is a top concern. Illegal immigration is impacting daily life in Boston, Manhattan, and Chicago. Public opinion on transitioning children is finally — mercifully — starting to sink. Fear is in the air, panic is contagious, and party discipline is creaking, if not yet cracking. Democrats are seriously worried about their electoral prospects. A party famous for its discipline and unity on the floor and in primaries (if not in Twitter spats) is splintering. Hillary Clinton threw her support behind a primary challenger against a sitting Democratic congressman, Squad member Jamaal Bowman of New York. Endorsements don’t often have as big an impact as people pretend, but that’s not the point. The point is the naked aggression against a sitting left-wing congressman from the former head of the party. A Thursday article in the heterodox, anti-groupthink British publication UnHerd finally highlighted the obvious problem facing Bernie Sanders, Vermont’s longtime “independent” senator and presidential primary darling. Called “Bernie Sanders has lost Vermont,” the piece explains the deepening divisions in the whitest state in the union and the loss of the working class. It was bound to happen. The quirky old man used to be a color-blind socialist who was OK with his state’s gun culture and had some more libertarian views. There’s no room for that in the new progressivism of the Democratic Party, and by the 2020 primary, he’d gotten the order and toed the line. And where is Joe Biden in all this? He’s staring blankly, wandering off stage, and moving like he’s made of brittle straw. The White House can deny it (and it does), but it’s plain to see. Fear is in the air, panic is contagious, and party discipline is creaking, if not yet cracking. On Wednesday, former President Donald Trump returned to D.C. to meet with Apple’s Tim Cook; JPMorgan Chase’s Jamie Dimon; the CEOs of Nasdaq, Citigroup, Wells Fargo, American Express, Bank of America; and about 70 other top business leaders who once turned their backs on him. He was well received. On Friday, Trump pulled ahead of Biden for the first time in 538’s election forecast. This thing is far from certain, and far from over, but if Trump wins in November, you can expect the slashing and cutting inside the Democratic Party to turn into whooping and shooting. The party of Jefferson and Jackson is heading toward civil war. UnHerd: Bernie Sanders has lost Vermont Sign up for Bedford’s newsletterSign up to get Blaze Media senior politics editor Christopher Bedford's newsletter.IN OTHER NEWS Target’s internal kiddie meltdown exposed Remember the Target boycott? It got less attention than Bud Light, but honestly deserved more. While Bud Light is guilty of disrespecting its customers, Target was marketing transexual clothing and bathing suits to children. Literally, children. Worse than that, it turned out the pervert in charge of this operation was donating portions of the profits to a nonprofit that worked to hide transitioning minors from their parents. So, targeting your kids in the store then using your money to permanently wound your children and disarm your parental rights. Pretty insane stuff. And the retail giant didn’t even apologize. The CEO was outright belligerent in defense of his company’s grooming. It did, however, stop targeting kids in all its stores. The heat was too much. But even that small retreat from grooming kids in Christian, rural areas was enough to cause an internal meltdown among far-left employees. Thanks to a leaker inside, Glenn Beck was able to expose it all on his Friday show. You can check it out here. Blaze TV Exclusive: Target insider exposes radicals on staff after pride backlash The Fire Rises: The Federalist: Massachusetts bill would allow women to sell their unborn children. The Massachusetts House of Representatives unanimously passed a bill Wednesday that would allow women to sell their unborn children to the highest bidder. Really. That means the political home of America’s abolition movement is back in the business of selling humans, but it’s OK because it’s in the name of rich gay privilege instead of rich farmer privilege. What forward-thinking times we live in. Patience Griswold reports: The “Parentage Equality” bill seeks to redefine parenthood. Parenthood is recognized on its natural biological basis, or in cases of adoption, justice for a child who has suffered loss by providing them with a safe, loving home. This bill redefines it on the basis of a “person’s intent to be a parent of a child.” In doing so, it strips all mention of mothers and fathers from parentage law, replacing these vital familial roles with gender-erased language. Finally, and most concerning, under H.4672, Massachusetts would allow for commercial surrogacy both in cases wherein the woman carrying the child is genetically unrelated to the child and in cases where she is exchanging her biological child for money.

A radical transvestite marched into a Christian elementary school in Nashville on March 27, 2023, and murdered three 9-year-old children — Evelyn Dieckhaus, William Kinney, and Hallie Scruggs — and three adults — teacher Cynthia Peak, custodian Mike Hill, and head of school Katherine Koonce. The Metropolitan Nashville Police Department refrained from announcing a possible motive for the attack, prompting months of speculation about its anti-Christian nature as well as the likelihood that LGBT activists' alarmist rhetoric and destabilizing sex-change drugs were factors. The FBI appeared especially keen to hide the transvestite shooter's motives from the public. After a year of uncertainty and Democrats exploiting the massacre to push gun bans, the truth has become abundantly clear, thanks to Michael Patrick Leahy, the CEO of Star News Digital Media and the editor of the Tennessee Star, who published the shooter's suicide note and other writings, which his paper obtained from an unnamed source some have suggested is close to the MNPD's investigation. It appears Leahy may ultimately pay a price for doing his job and protecting his source. After Stacy Cameron, a reporter for a local Fox News affiliate, effectively snitched on the Tennessee Star for detailing the shooter's leaked writings, l'Ashea Myles — the Democratic judge for Part III of the Tennessee 20th Judicial District Chancery Court — ordered Leahy last week to court for a show cause hearing. 'This very lower, lower, lower court judge is being pressured by somebody far above her pay grade.' The purported point of the hearing, set to take place Monday, is "to determine why the alleged publication of certain purported documents by Petitioners Star Digital Media and Michael Leahy, as the Editor-in-Chief, does not violate the Orders of this Court subjecting them to contempt proceedings and sanctions." Blaze News investigative reporter Steve Baker, who himself was arrested earlier this year for working in a journalistic capacity, will be on the scene for the hearing and has spoken with Leahy concerning the hazards of reporting on what the liberal media appears otherwise keen to ignore. "My feeling is that this very lower, lower, lower court judge is being pressured by somebody far above her pay grade to bring action here against a local journalist who legally acquired documents and information about one of the most substantial shootings in the country last year," Baker told Blaze News. "This was obviously a situation where the FBI did not want these documents out, did not want the manifesto out." Baker suggested that the apparent aim is to stop the release of documents that the powers that be "see as inappropriate because, once again, we have a favored class of citizens — a subclass — of transgender people," and such damning information might also implicate the use of profitable antidepressants and puberty blockers. 'The documents are public record, and they should be released.' Blaze News reached out to the ACLU as well as its Nashville chapter about the prospect that a newspaper man might be punished for doing his job. Neither responded by deadline. PEN America and Freedom House similarly did not respond to questions about their ostensibly selective support for embattled reporters. Background When it became clear that officials weren't going to cough up a motive or the shooter's writings, the Tennessee Firearms Association and the Nashville Police Association unsuccessfully sued, demanding that officials release the killer's manifesto and other writings. When the FBI denied its public records request, Leahy's Tennessee Star also filed a lawsuit. "The documents are public record, and they should be released. Metro government failed to release them; we asked them nicely. They didn't. They shared those documents with the FBI, and we asked them nicely in accordance with the law. When government entities don't comply with the law, we have recourse through the courts," said Leahy. Extra to pressure from the free press and local organizations, law enforcement officials were met with a request from 77 Tennessee House Republicans for the transvestite shooter's "writings as well as relevant medical records and toxicology reports." The MNPD dragged its feet and asked a court to first permit family members of the victims and other interested parties to raise objections to the release of the documents. Sure enough, the Covenant Presbyterian Church and the associated school filed a motion to block the release of the manifesto, citing privacy concerns. Parents with children at the school also filed a motion in May 2023 against the release of the manifesto, expressing concern that its content might inspire future shootings — a line of argumentation nearly identical to that advanced by the FBI that same month. Blaze News previously reported that officials with the FBI's Critical Incident Response Group wrote to Nashville Police Chief John Drake on May 11, 2023, about the value in suppressing so-called "legacy tokens," claiming that "public access to legacy tokens will contribute to future attacks." The FBI also warned that a failure to hide the truth from the public "will also facilitate false narratives and inaccurate information" — and possibly even inflammatory "conspiracy theories" by unsanctioned experts. The success of this apparent federal-supported coverup was endangered when conservative commentator Steven Crowder released three pages of the manifesto, which were later authenticated. Nashville's Democratic mayor vowed to investigate the leak, and seven MNPD officers were placed on administrative duty. The investigation proved fruitless. The matter of the release of the remainder of the documents remained under consideration in Myles' Davidson County court. Ordering a newspaper man to court Deborah Fisher of the Tennessee Coalition for Open Government noted that Myles issued an order in February stating that documents pertaining to the case about the documents, "no matter how obtained ... SHALL NOT be filed with the Court but SHALL BE submitted for in camera review following the procedures delineated in this case. … Any efforts to usurp the Orders of the Court by any Party, Counsel and/or Amici regarding the matters currently under in camera review shall be sanctioned to the fullest extent of the law, including contempt of court." This and a follow-up order appear to be the orders Leahy is imagined to have run afoul of. After the Fox News affiliate asked Myles about the Tennessee Star's reports earlier this month — which revealed, among other things, that the FBI floated the idea of destroying the shooter's writings and the shooter received decades of treatments at Vanderbilt Psychiatric, where she allegedly expressed violent fantasies — the judge ordered Leahy in his individual capacity to show up for a show cause hearing. Daniel Horwitz, counsel for Leahy, stated in a June 12 court filing that the court's show cause order violates Tennessee's shield law protecting journalists' sources and information, whether obtained confidentially or not. Horwitz also suggested that the newly minted Democratic judge's order also contravenes Tennessee's contempt law, "deprives Mr. Leahy of minimum due process guarantees," and suffers from "other serious constitutional infirmities." The court filing further indicated that Myles' order did not specify the "Orders of this Court" that were supposedly violated. 'This is what the free press is for.' "In contempt proceedings, 'the order underlying the charge must be clear, specific, and unambiguous,'" wrote Horwitz. "The conduct detailed in the Court's Show Cause Order does not plausibly violate any of [the court's] previous mandates." Myles refused to rescind her order, noting that if she concludes "a leak did in fact occur by any party to this case and that such action was in violation of the Orders of this Court, or that there has been any abuse of, or unlawful interference with, the process or proceedings of the Court, or any violation as set forth in Tennessee Code Annotated § 29-9-102, this Court may then enter an order and notice appointing an attorney as amicus curiae to the court for investigative purposes, and to initiate and prosecute a contempt citation." Baker indicated that if held in contempt, Leahy noted he could get 10 days for each supposed violation. With at least 30 offending stories published this month, it is apparently possible that the newspaper man could land hundreds of days in the slammer. When speaking to the newspaper man this week about the prospect of legal strife over the faithful execution of journalistic duties, Baker said, "Welcome to the club." Leahy suggested to Baker that 10 days would be a walk in the park. Hundreds of days for fulfilling his obligation as a newsman would, however, be a different story. Former acting U.S. Assistant Attorney General Jeff Clark spoke out in defense of Leahy Thursday, noting, "What's being threatened against Mike Leahy seems to be a strange amalgam of 1) violating the First Amendment ban on prior restraints on speech; 2) a threatened mystery violation of law just like the Alvin Bragg case against Trump ('step right up, ladies and gentlemen, pick a plus-up crime, any plus-up crime'); and 3) weaponization of contempt law, like what's going on down in Fulton County with Judge Glanville in the Young Thug trial." "What's going on in America? It's like a slice of the state judiciary across multiple States has lost its collective mind," added Clark. "The American people deserve to know the details of how Hale was radicalized by the trans agenda. And the victims' family especially deserve to learn that information. This is what the free press is for," continued Clark. "It's not designed to coddle the trans movement or keep secrets that could get people killed through ignorance." State Rep. Jeremy Faison (R) noted the Tennessee Legislature "will not stand for an activist judge who weaponizes their courtroom. [Leahy] is the press and does not have to prove to any courtroom that he is innocent." Republican state Sen. Ken Yager said he would sponsor Faison's resolution to remove "judges engaging in abuse like this." Concerning the liberal media and supposed press freedom groups' relative silence on Leahy's court appearance Monday, Baker indicated that either the First Amendment "is fundamental to the freedom of all people or it's only based on ideological preference." "Very interesting to me that over and over and over again I hear conservatives, libertarians say, 'I will die for your right to say what you want to say even if I disagree with it. But we never get a reciprocal response from the other side," added Baker. Like Blaze News? Bypass the censors, sign up for our newsletters, and get stories like this direct to your inbox. Sign up here!

LOL! In Honor of Chuck Schumer's HUMILIATING BBQ Debacle Here's OTHER Dems Failing to Fake Being Normal

Here's the Angle Dems/Media are Using to Debunk Video Showing Biden Being Led Off Stage

Alaska Man Monday - Snow Machines, Russians, Booze, and Guns