The World Health Organization on Monday released new guidance on GLP-1 medications for adults with obesity, recommending their long-term, continuous use when clinically appropriate. The medications covered include semaglutide (Wegovy), liraglutide (Saxenda) and tirzepatide (Zepbound). The recommendations, published in the medical journal JAMA, emphasize that these medications alone are not a solution to treating the global obesity epidemic. Obesity is a chronic disease that needs lifelong care and is best treated with long-term GLP-1 use combined with a structured program that includes healthy eating, regular movement and ongoing counseling to lose and maintain weight loss, according to the WHO...

The World Health Organization on Monday issued its first guideline on the use of GLP-1 therapies for obesity, conditionally recommending them as part of long-term treatment for the condition, which affects more than 1 billion people globally according to the agency. Reuters first reported that the WHO was likely to take this step earlier this year. The guidance comes as demand for the class of drugs known as GLP-1 agonists has surged worldwide, and governments are figuring out how to include the blockbuster therapies into public health systems...

Popular drugs like Zepbound and Wegovy that promise a slimmer profile can trigger much more than weight loss. These medications can spur a slew of potential side effects, like nausea, vomiting, constipation, diarrhea, headaches and changes to the skin. One possible consequence is especially dire for the 10 million Americans using GLP-1s...

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