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Science Explorer
Science Explorer
1 y

Male Birth Control Pill That’s Safe, Reversible, And Hormone-Free Could Be Inching Nearer
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Male Birth Control Pill That’s Safe, Reversible, And Hormone-Free Could Be Inching Nearer

When it comes to birth control, there’s a bit of an imbalance between products targeted at women and those assigned female at birth, and products targeted at men. And when we say “imbalance”, we mean that nearly all the effective, reversible methods are designed around the female reproductive system. There’s long been a drive to try and redress this with the development of a male contraceptive pill, and a new study has found a promising option that’s already seen success in animals.“Although researchers have been investigating several strategies to develop male contraceptives, we still do not have a birth control pill for men,” said corresponding author Dr Martin Matzuk of Baylor College of Medicine in a statement.“In this study we focused on a novel approach – identifying a small molecule that would inhibit serine/threonine kinase 33 (STK33), a protein that is specifically required for fertility in both men and mice.”This new approach does not rely on manipulating hormone levels, like many existing contraceptives. Instead, like some other male contraceptives that are being explored, it has been born out of genetic research.The drug targets the STK33 protein, which is expressed at high levels in the testes and has been shown to be essential for proper sperm development. Natural mutations in the STK33 gene are a known cause of infertility in men; but, while the quality of the sperm is affected, there is no change in the external appearance of the testes, or any other identifiable issues.“STK33 is therefore considered a viable target with minimal safety concerns for contraception in men,” Matzuk explained.The team set about screening billions of compounds, trying to find one that might work to inhibit STK33 – an effort aided by the fact they also managed to elucidate the crystal structure of the protein for the first time.Several candidates were taken forward for further modifications and experiments, and one emerged at the head of the pack. “Among these modified versions, compound CDD-2807 turned out to be the most effective,” said staff scientist and first author Dr Angela Ku.Previous work in a mouse model had shown that knocking out their matching Stk33 gene has the same effect as it would in human males – it causes infertility by negatively affecting sperm quality. The team therefore tested out their CDD-2807 compound in mice to assess its potential as a contraceptive.The drug was able to successfully migrate into the testes, reducing sperm count and motility. Testis size was not impacted, and there were no toxic side effects.“Importantly,” explained co-author Dr Courtney M. Sutton, “the contraceptive effect was reversible. After a period without compound CDD-2807, the mice recovered sperm motility and numbers and were fertile again.”The achievement was hailed as a “tour de force” by co-author Dr Mingxing Teng, and Matzuk explained that the next step will be to test out the compound in primates.This is not the first hormone-free male contraceptive that’s shown promise in the lab. Another compound, YCT-529, is already in early clinical trials. Other approaches being explored put a temporary block on sperm production itself, render sperm unable to swim, or act as a reversible alternative to a vasectomy.But the process of drug development is long and, given the desert of contraceptive options for men up to now, there would certainly be no downside to additional choices. Which birth control method you opt for is a very personal decision, so in an ideal situation, we’d have a range of options to suit different people.Perhaps this time, the promise of a male contraceptive is finally coming closer to fulfillment.The study is published in the journal Science. 
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Science Explorer
Science Explorer
1 y

Volcanoes On Venus Might Still Be Erupting In Widely Spread Locations
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Volcanoes On Venus Might Still Be Erupting In Widely Spread Locations

Two lava flows on Venus show signs of being very recent, suggesting volcanic activity on Earth’s evil twin may be ongoing, providing exciting opportunities for future study.It’s hard to believe today, but in the middle of the last century, hopes for life or future colonies on Venus were as high as for those on Mars. We soon learned that the planet was dead biologically (some recent debate about the upper atmosphere aside), and the same was thought to be true geologically, since it lacked plate tectonics. Attention turned elsewhere.Now, however, Venus is having a bit of a resurgence. The latest step involves planetary scientists spotting changes at two locations between images taken in 1990 and 1992 that might be signs of fresh lava flows.Last year, data from the Magellan orbiter taken back in the 1990s was found to show changes around a suspected volcanic vent between two radar mapping cycles. The team that spotted it thinks lava escaped in between. Shortly afterwards a map of 85,000 Venusian volcanoes was published. Although most of these are almost certainly extinct, it is hoped the map could be used to spot any that might still be active.The plan seems to have worked. Dr Davide Sulcanese of Università d’Annunzio and co-authors searched through the Magellan images to look for changes. The process is not as easy as it might sound, because the orbiter was not in identical positions when areas were mapped on the two passes, so variations in angles make places look different.However, after weeding out a variety of false changes, the team consider changes on the western flank of the volcano Sif Mons, and in western Niobe Planitia, to be the real thing. “We suggest that these changes are most reasonably explained as evidence of new lava flows related to volcanic activities that took place during the Magellan spacecraft’s mapping mission,” they write.The authors chose Magellan’s first and third mapping cycles, because the viewing angles are more similar to each other than either is to cycle 2. The maps the team used have a pixel size of 75 meters, so any activity needs to be substantial to be detected. “Our results show that Venus may be far more volcanically active than previously thought,” Sulcanese said in a statement.Neither of the changes observed can be conclusively identified as lava flows at this resolution, but the team rejected all the alternative explanations they could think of, such as atmospheric effects or landslides. Moreover, going from a single event that might have other explanations to three means that if something else is responsible, it must be quite widespread, rather than a fluke event.The three locations are so dispersed across Venus they can’t be connected; if all are real, we can expect eruptions to be a frequent event.Sif Mons is a broad shield volcano where about 30 square kilometers (12 square miles) appear to have changed between passes; “Brighter regions observed in cycle 3 appear to completely cover some of the darker flows seen in cycle 1,” the authors report.Nibie Planitia is almost 100 degrees of longitude away from Sif Mons, and the terrain is flat, making landslides unlikely. Fan-shaped features appear there in the third cycle that cannot be seen in either of the other two.In both cases, the new bright areas appear to deviate around topographical obstacles, just as lava would.Without knowing the depth of lava, little precision about the volume released is possible. Nevertheless, the team estimated rates of flow just from these sites similar to the annual average on Earth over the last 180 million years. “Therefore, following these calculations, not only might Venus be far more volcanically active than previously assumed, but its volcanic activity could also be of the same order of magnitude as that estimated for Earth,” they write. Given the absence of Venusian plate tectonics – the primary driver of volcanism on Earth – that would be a remarkable finding, and one geologists would be keen to investigate. It certainly looks like there will be something worth investigating for future missions. Already, Dr Suzanne Smrekar of JPL has indicated the VERITAS mission may focus on these sites when it reaches Venus.The study is published open access in the journal Nature Astronomy.
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The Blaze Media Feed
The Blaze Media Feed
1 y

America's first Bitcoin president: Trump starts taking crypto donations
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America's first Bitcoin president: Trump starts taking crypto donations

This article originally appeared in Bitcoin magazine. President Trump, in a press release published on his website this last week, announced that his campaign to take back the White House will begin accepting donations using Bitcoin.This announcement by his campaign is sure to stoke the fires between Trump and the incumbent President Joseph Biden, who alongside fellow Democrat Senator Elizabeth Warren (D-Mass.) has spent the majority of his term in Washington waging an all-out regulatory attack against the digital asset space and Bitcoin in particular. "As our President, Donald J. Trump has reduced regulations and championed innovation in financial technology, while Democrats, like Biden and his official surrogate Elizabeth Warren, continue to believe only government has the answers to how our nation leads the world," the announcement stated. "The effort to reduce the control of government on an American’s financial decision-making is part of a seismic shift toward freedom. Today’s announcement reflects President Trump’s commitment to an agenda that values freedom over socialistic government control."As Bitcoin magazine made note in its Orange Party Issue, Trump’s appointment of former Coinbase VP Brian Brook as the comptroller of the currency was “the single most important Bitcoin-forward move in the history of the United States,” as it allowed banks and financial firms to hold cryptocurrencies. This ruling went into effect midway through the last year of Trump’s first term, and Bitcoin’s price multiplied around 20 times in just the next calendar year.The Trump administration has been no stranger to Bitcoin over the years, with the appointment of longtime Bitcoin and crypto proponent Mick Mulvaney as his White House chief of staff, as well as PayPal’s Peter Thiel making an appearance on his transition team.Trump also made history by being the first U.S. president to embrace non-fungible tokens with his incredibly successful Trump Cards that sold out at the end of 2022. In yet another historic first not to be forgotten, Melania Trump was the first first lady to tweet about Bitcoin creator Satoshi Nakamoto’s contribution to the financial system at the start of 2022, referencing the January 3 anniversary of the Genesis Block that kick-started the Bitcoin blockchain.In January at a campaign stop in New Hampshire, Trump promised that when he is elected, he will not allow the Federal Reserve to create a central bank digital currency. “Tonight, I am also making another promise to protect Americans from government tyranny,” Trump said. “As your president, I will never allow the creation of a central bank digital currency.”As for the campaign donations themselves, the announcement specified that donors would be able to send Bitcoin and other cryptocurrencies to the Trump 2024 campaign via Coinbase, the only publicly listed Bitcoin exchange in the United States."Biden surrogate Elizabeth Warren said in an attack on cryptocurrency that she was building an 'anti-crypto army' to restrict Americans’ right to make their own financial choices," the announcement continued. "MAGA supporters, now with a new cryptocurrency option, will build a crypto army moving the campaign to victory on November 5th!"For details on how to donate to the Trump 2024 campaign, visit the campaign website here.Bitcoin magazine, the most trusted voice in Bitcoin, stands proudly at the forefront of technology and economics, telling the stories and platforming the people using code to liberate humanity from government money. It will be collaborating with Return on a series of articles about Bitcoin and its essential place in the modern world.
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The Blaze Media Feed
The Blaze Media Feed
1 y

The Home Depot Option: Why we homeschool our nine kids
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The Home Depot Option: Why we homeschool our nine kids

I recently had a memorable stroll through Home Depot with seven of my children. As I was leaving the screw aisle for the wood aisle, a clerk asked me: “Are all of those yours?” “Yes,” I replied. “One hundred percent natural.” We practice these virtues in our home classroom when a bigger kid explains to a younger the differences between compound and simple leaves or changes the baby’s diaper while mom explains long division to a younger. He proceeded to shake my hand and commented: “I thought maybe they were cousins.” I answered: “If they were here, I’d have about fifty kids with me.” As I completed my purchase of the materials I needed to build my daughter’s birthday gift, another clerk commented on the quantity of my progeny, remarking at how well behaved they were. “Where do you go to school?” she asked them. “We’re homeschooled,” they replied. Woke 101 I am not someone you would expect to become a homeschooling dad with nine kids by the age of 37. As an early Millennial, I am part of the overwhelming majority of my generation who attended public schools – around 90%. Most of the remaining 10% attended private schools, and less than a million – or less than 2% – of students were homeschooled. The general assumption for most of my generation was that our children would also attend public schools. But the public schools of today are very different from those of 1990s middle-class suburbia. In the last couple of years, parents have increasingly taken notice of how the woke revolution fueled by identity politics has infiltrated their schools, from pornography in their libraries to coerced racialized struggle sessions and transgender bathroom policies that have allegedly led to sexual assaults and subsequent cover-up. In the latter case, the alleged victim’s father’s rowdy protest at a school board meeting was one event cited by the National School Board Association’s call for President Biden’s Department of Justice to leverage the FBI and the federal counterterrorism bureau to intervene. The invitation to investigate concerned parents as domestic terrorists was initially accepted by the Biden administration. If there are any benefits to an education increasingly infused by identity politics, improved performance in math and reading are apparently not among them. In the most recent NAEP national report card, there was a historic decline in performance in reading and math. The average reading score for fourth-graders over the past couple years, already well below “proficient,” underwent the steepest decline in over 30 years. And math scores dropped for the first time ever. It is established that children who cannot read by the fourth grade are drastically more likely to struggle with reading the rest of their lives and experience a whole range of negative outcomes, including poverty, crime, and incarceration. It therefore seems undeniable that America is at a crossroads. How shall we educate our children? While the woke revolution has been met with political resistance from the right with some successes, in many places it will prove to be too little, too late. The duty of dropping out Parents have a natural moral duty to educate their children, which is the ground of their natural right to educate them as they see fit. Given the trajectory of public school education, parents have a duty and a right to re-evaluate it and seriously consider withdrawing their children from the public school system entirely. It is parents’ civic duty as well, inasmuch as we are all members of the American polity. A society, Edmund Burke taught us, is a partnership across generations, between the dead, the living, and the unborn. Each generation is therefore an inheritor of the traditions and institutions its (great-) grandparents and parents have bequeathed. And each generation cannot escape the duty to evaluate what has been received, preserve what merits preserving, and reform what does not contribute to the common good. What I have found is that, very often, old things that were once discarded need to be rediscovered again. This is especially true in education. In "After Virtue," Alasdair MacIntyre concluded his survey of the moral and political detritus wrought by advanced modernity by calling for a new, doubtless very different, St. Benedict to advocate for and maintain traditional virtues. As MacIntyre penned those words, the homeschool movement was already under way; many commentators have noted that it is very much in the spirit of MacIntyre's call. As the Benedictine monasteries of old kept classical learning alive after the collapse of the Roman empire and the advance of barbarism, so homeschools today are outposts of broadly teleological, classical education in the late-modern wasteland. The recent spike in homeschooling by a factor of five to 10 across races and ethnicities suggests that more and more American parents agree. Why we took the leap While my wife and I have homeschooled all our children, this was not a foregone conclusion. It was less likely considering that the only homeschoolers I knew growing up seemed to me to be an assortment of religious weirdos, socially awkward dorks who played board games because they were no good at sports, and girls who wore abnormally long skirts. Of course, I later realized that those beliefs were as silly and shallow as they were widespread. Why my change of heart? You could chalk it up to my conversion to Catholicism and embrace of its traditional moral teachings, and the basic God-given duty is to do all that I can to help my kids get to heaven. As well as the example of family and friends successfully educating their children at home. But the arguments for homeschooling alone were insufficient for both my traditionalist Catholic wife, who was very much opposed to homeschooling during our courtship and early marriage, and me. Just as important were the arguments against public schools. Like many parents who choose to homeschool, I'm worried about the dangers lurking in the public school environment: drugs, peer pressure, violence. At the same time, many of us lack faith in the public school systems' capacity to educate. The controversy over reading pedagogy is illustrative. For decades, most schools have been taken in by so-called “whole language” or “balanced literacy” approaches to reading, which de-emphasize traditional systematic instruction in phonics as rigid and outmoded. Even though the science of reading clearly demonstrates that the older phonics method is superior, as of 2019, 72% of K-2 teachers reported using “balanced literacy.” I confess I knew little of the reading wars when I first sat down with my oldest and started teaching him phonics with homeschool resources like "Bob Books." As I have taught each of my subsequent children how to read and myriad other things, I discovered that the pedagogy of reading is synecdochic for the whole of education: Rediscovery of the old is the key to rebuilding it anew. With two working parents trying to hold together an orderly homeschool room while also raising preschool-aged kids, a strong foundation in reading and writing turns out to be essential. It enables significant independence in the pupil to learn through textbook reading and workbook problems while allowing the parent to give individual attention where it is needed. How? For what purpose? Why not send my kids to a private school with a morally serious environment and sounder pedagogy? As is the case for many Americans, I simply don't have the money. To send my school-age kids to one of the more affordable local private Christian schools would cost more than double my annual mortgage. Of course, homeschooling is not necessarily prudent for every situation. But it is notable that many who homeschool are of modest means. While we are fortunate enough to be well educated and work jobs with flexible hours, those benefits are themselves the product of much sacrifice. As with anything worth doing well, no homeschool is without it. While some states are moving in the right direction by broadening financial support for educational choice, my wife and I realized that, even if we had state support, we would still probably homeschool. Many private schools have integrated newfangled and pedagogically questionable personal electronic devices and screens into the classroom, which also risks undermining their environmental health. I am but a humble homeschooling dad, but in our school, we have found that tuition is considerably more affordable when we stick to pencil and paper. And the lessons stick, too. Make the old new again. Of course, pencil and paper were once new technologies. And it would be incredibly naïve to deny that the new is much of the warp and woof of our lives. Whatever its demerits, we live and breathe and often benefit from the new. Indeed, I have taught my children these very lessons using Leonard Read’s little book "I, Pencil," which shows how rational self-interest, combined with specialization of knowledge and labor, technology, integrated free markets, and profit-incentivized innovation, makes it possible for me to stroll through Home Depot and conveniently and cheaply purchase wood and screws. But how? And for what purpose? Neither techne nor the market can answer these questions. Home Depot pedagogy Our Home Depot trip illustrates our answers to the questions of how and why. Each of my three oldest are assigned to help with one younger child, and the littles know they are supposed to respect them. Even during a simple trip to a big-box store, they were practicing the virtues characteristic of order, of giving and receiving. We practice these virtues in our home classroom when a bigger kid explains to a younger the differences between compound and simple leaves or changes the baby’s diaper while mom explains long division to a younger. How do we do it? By developing and practicing the habits of sharing the load together. Perhaps the clerks were struck by my kids precisely because their lived answer to the how question was in contradiction to the spirit of our age. When I asked my daughter Belén what she wanted for her birthday, she replied: “I want a bookshelf like Cormac has.” Last Christmas I built a bookshelf for her older brother that stretches the seven-foot length of the top bunk of the boys’ triple bunk bed. He had run out of space on the bookshelf for his approximately 120 books. And now my eldest daughter’s book collection has outgrown her shelf. So with my daughter helping me, I showed her how to cut the boards, how to drill the pocket holes, and how to join the boards with screws and glue. Then we painted it. How? Together. For what purpose? If that isn’t apparent yet, allow me to state it in the admittedly old terminology of Aristotelian-Thomistic philosophy. It is the end that is distinctive of human beings, given our nature as dependent rational animals: the good of the intellect. Our purpose, like the homeschool movement more broadly, is to seek truth together. And if you haven’t already, you should consider joining us.
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RedState Feed
RedState Feed
1 y

'Full-Blown Freakout,' Democrats Are Having a Panic Attack Over Joe Biden's Electoral Prospects
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'Full-Blown Freakout,' Democrats Are Having a Panic Attack Over Joe Biden's Electoral Prospects

'Full-Blown Freakout,' Democrats Are Having a Panic Attack Over Joe Biden's Electoral Prospects
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The Story a Black Rock Told Me on a Montana Mountain
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The Story a Black Rock Told Me on a Montana Mountain

The Story a Black Rock Told Me on a Montana Mountain
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1 y

Tuesday Morning Minute
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Tuesday Morning Minute

Tuesday Morning Minute
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Democrats Collude with Big Tech: History of Technology in Politics
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Democrats Collude with Big Tech: History of Technology in Politics

Democrats Collude with Big Tech: History of Technology in Politics
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Trending Tech
Trending Tech
1 y

iPad 10 got a price cut, but buying one from Apple is still a mistake
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iPad 10 got a price cut, but buying one from Apple is still a mistake

When Apple launched its new M4 iPad Pro and M2 iPad Air tablets, there was no new entry-level iPad to go along with them. If you follow along with Apple rumors though, you knew not to expect one. Instead, the iPad 10 stayed in Apple's lineup at a new price point of $349 instead of $449, while the iPad 9 was finally put out to pasture. Even at the new, lower price, however, it's still a mistake to buy an iPad 10 directly from Apple. That's the case with most Apple products, and it's because other retailers offer much better prices. As I explained, the 64GB version of Apple's iPad 10th-Gen now costs $349 following Apple's price cut, but it's currently on sale for just $299.99 for the first time ever. Needless to say, that's an all-time low for this model. The deal is only available at Amazon for the time being, but Best Buy usually follows Amazon's lead. Of note, that's the lowest price ever for this model. You can also save $50 on the 256GB model if you need more storage. Or, if you want to spend even less money, the previous-generation 10.2-inch iPad 9th-Gen is also on sale starting at just $249. Apple iPad (10th Generation): with A14 Bionic chip, 10.9-inch Liquid Retina Display, 64GB, Wi-F… Price: $299.99 (reg. $349) Buy Now Apple iPad (10th Generation): with A14 Bionic chip, 10.9-inch Liquid Retina Display, 256GB, Wi-… Price: $449.99 (reg. $499) You Save: $30.00 (6%) Buy Now Apple iPad (9th Generation): with A13 Bionic chip, 10.2-inch Retina Display, 64GB, Wi-Fi, 12MP… Price: $249 (reg. $329) You Save: $80.00 (24%) Buy Now Apple iPad (9th Generation): with A13 Bionic chip, 10.2-inch Retina Display, 256GB, Wi-Fi, 12MP… Price: $379 (reg. $479) You Save: $100.00 (21%) Buy Now There are several things that make the new iPad 10th-Gen tablet a solid upgrade from its predecessor. The first and most obvious update is the design of the iPad 10. It has a slightly larger display than the 10.2-inch model, of course. But it also has smaller bezels because the home button underneath the screen has been removed. You can still use Touch ID on the iPad 10, though it has simply been moved to the power button on the edge of the tablet. This is a big deal for many Apple fans out there. Yes, Face ID is great. I personally prefer it to Touch ID on my iPhone. But on an iPad, I'm not such a big fan. Sometimes, I just don't hold the iPad in a position that works well for Face ID, and it takes a few tries to unlock it. That's not a great user experience at all. Meanwhile, Touch ID works every single time for me, without fail. Apple's 10th-generation iPad also features the powerful A14 Bionic chipset in place of the A13 chip in the 9th-generation iPad. You get big speed gains as well as better battery life and more. Also of note, it's the cheapest iPad you can get that will work perfectly with the new USB-C Apple Pencil (currently $10 off). The only less expensive iPad is the 9th-gen model, but it has a Lightning port instead of a USB-C connector. Apple iPad (10th Generation): with A14 Bionic chip, 10.9-inch Liquid Retina Display, 64GB, Wi-F… Price: $299.99 (reg. $349) Buy Now Apple iPad (10th Generation): with A14 Bionic chip, 10.9-inch Liquid Retina Display, 256GB, Wi-… Price: $449.99 (reg. $499) You Save: $30.00 (6%) Buy Now The 10.9-inch iPad now starts at $349, which is a big price cut compared to the launch price. Right now, however, Amazon's iPad 10 deals start at $299.99. You can also upgrade to the 10.9-inch iPad with 256GB for $449.99 instead of $499. As I mentioned, however, the previous-generation iPad model is also on sale. It has been removed from Apple's lineup since the iPad 10th-Gen got a price cut. But you can still find this old model in stock with steep discounts until it sells out. You can get the 256GB model on sale for $379 instead of $479, which is a $100 discount. Also, WiFi + Cellular models are up to $80 off right now. Or, if you want to spend as little as possible, you can opt for the base model with 64GB of storage. The 64GB iPad 9 retails for $329, but it's currently on sale for $249 for the entry-level model. That's a nice big discount, and it matches this model's lowest price since the holidays last year. Apple iPad (9th Generation): with A13 Bionic chip, 10.2-inch Retina Display, 64GB, Wi-Fi, 12MP… Price: $249 (reg. $329) You Save: $80.00 (24%) Buy Now Apple iPad (9th Generation): with A13 Bionic chip, 10.2-inch Retina Display, 256GB, Wi-Fi, 12MP… Price: $379 (reg. $479) You Save: $100.00 (21%) Buy Now Don't Miss: Memorial Day deals: $189 AirPods Pro, $43 camera drone, $179 Roomba, Crest 3D Whitestrips, Instant Pot, more The post iPad 10 got a price cut, but buying one from Apple is still a mistake appeared first on BGR. Today's Top Deals Best deals: Tech, laptops, TVs, and more sales Today’s deals: Memorial Day sales on Dyson vacuums, WiFi 6 routers, NERF guns, Ray-Ban sunglasses, more Today’s deals: $3.25 smart plugs, $79 AirPods, $849 M2 MacBook Air, $329 Sony WH-1000XM5 headphones, more Best Apple Watch deals for May 2024
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1 y

Belgium Commits $1 Billion to Ukraine in New Security Pact
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Belgium Commits $1 Billion to Ukraine in New Security Pact

Ukrainian President Volodymyr Zelenskyy on Tuesday received a second $1 billion promise of military aid in as many days for his war with Russia during a whirlwind tour through the European Union.
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