It’s that time of year with Christmas parties abound‚ and also the time of year when many people will be standing in line for a club‚ meeting the eyes of bouncers‚ and suddenly realizing they may have had one free drink too many. Whilst there are folk remedies galore for sobering yourself up enough to be allowed in and cut some dodgy shapes on the dancefloor‚ they also rarely work. Thankfully‚ scientists are on the job of finding a solution.Take a deep breathThough designed primarily as a rescue therapy for severe alcohol intoxication‚ researchers have been working on a simple method to eliminate alcohol from the body: breathing.The liver is responsible for clearing more than 90 percent of the alcohol in a human body; in this case‚ only time will help you to fully sober up‚ as the liver does its job at a constant rate that can’t be increased. For people with life-threatening blood-alcohol concentration‚ this leaves medics with few treatment options beyond supportive measures like giving oxygen and intravenous fluids.What the researchers‚ led by Dr Joseph Fisher‚ looked to target was the remaining 10 percent – some alcohol is eliminated by the lungs. They hypothesized that the harder someone breathed‚ the more alcohol would be expelled. "But you can't just hyperventilate‚ because in a minute or two you would become light-headed and pass out‚" explained Fisher in a statement. Instead‚ the researchers created a device that allowed hyperventilation levels of breathing without the nasty side effects. "It's very basic‚ low-tech device that could be made anywhere in the world: no electronics‚ no computers or filters are required‚” said Fisher. In a proof-of-concept study group of five healthy men with around a 0.1 percent blood alcohol concentration‚ alcohol was eliminated at least three times faster than through the liver alone.Given the small sample size of this study‚ further research would be required to validate the device before it could reach a clinical setting‚ let alone someone’s bag on a night out. Fisher remained optimistic‚ telling Thornhill Medical: “I am hopeful that with further validation studies‚ our method can easily become a standard approach to treat many types of poisonings around the world‚ saving many with carbon monoxide‚ ethanol‚ methanol and solvent poisoning.”(Hormone) shots‚ shots‚ shotsShots might not sound like the solution to drunkenness‚ but they potentially could be if that shot is actually an injection of fibroblast growth factor 21 (FGF21).FGF21 is a hormone released by the liver in times of metabolic stress‚ such as downing large quantities of alcohol. While previous studies have suggested it might help to increase thirst to prevent hydration‚ suppress the desire to knock back another pint‚ and protect the liver against injury‚ research published earlier this year concluded that it could also help to restore balance and coordination – in mice‚ at least. The team gave alcohol to both mice genetically modified to not produce FGF21 and a control group –sadly‚ not in tiny pint glasses. They discovered that whilst ethanol was broken down are the same rate in both‚ it took longer for the genetically altered group to recover their balance. When given an injection of FGF21‚ however‚ those mice were able to “sober up” and regain their balance around 50 percent more quickly than those given a control treatment.“We’ve further shown that by increasing FGF21 concentrations even higher by injection‚ we can dramatically accelerate recovery from intoxication‚” said co-senior study author Steven Kliewer in a statement.Kliewer further explained that FGF21 exerted this effect by activating a part of the brain associated with alertness: the locus coeruleus‚ which is found in the brainstem. Quite how it achieves this is unclear and there’s no saying that the same effect would be seen in the human brain‚ although the team is working on solving at least the latter of those questions.“Our studies reveal that the brain is the major site of action for FGF21’s effects‚” said fellow co-senior study author David Mangelsdorf. “We are now exploring in greater depth the neuronal pathways by which FGF21 exerts its sobering effect.”For now at least‚ sobering up quickly doesn’t seem to be an option – so maybe go easy on the festive tipples if you want to make sure all your colleagues get to bear witness to your funky fresh dance moves.

The founder of Facebook is investing in his future by building a $100 million doomsday complex in Hawaii. Mark Zuckerberg takes a unique approach to ensuring safety and comfort in the event of global change and creates his own island reserve bunker. According to the project‚ the complex will be located on the island of Kauai and will include several buildings‚ including two main mansions‚ connected by a tunnel that leads to a huge underground bunker covering an area of ​​5 thousand square feet. This bunker will be equipped with an escape hatch and a blast-proof door‚ providing a safe haven in the event of a disaster‚ reports wired.com. Additional amenities include no less than 30 bedrooms and 30 bathrooms‚ guest houses‚ and a unique group of 11 “disc-shaped” tree houses connected by rope bridges. Upon completion of the project‚ the complex will also include a six-metre high and 18-metre diameter water tank‚ as well as 1‚400 acres of agricultural land‚ providing food and energy independence. Construction on Zuckerberg’s compound‚ called Koolau Ranch‚ is estimated to cost around $100 million; coupled with the $170 million spent on the land for the property‚ the total price tag sits around $270 million‚ though that’s likely still an underestimate‚ according to Wired. Zuckerberg’s not the first tech titan to build a home ready for the end of the world. Very rich people are rapidly preparing for something. OpenAI’s ousted-and-reinstated CEO Sam Altman has a stash of things like guns‚ gold‚ antibiotics‚ and gas masks. Reddit CEO Steve Huffman bought motorcycles‚ guns‚ and ammo to be prepared to “hole up in my house for some amount of time” if necessary and even got laser eye surgery because he thinks it’d help his odds of survival in a disaster. LinkedIn cofounder Reid Hoffman once told the New Yorker he estimates more than half of Silicon Valley billionaires have invested in some type of “apocalypse insurance‚” like an underground bunker. The post Mark Zuckerberg is building an Apocalypse-proof bunker appeared first on Anomalien.com.

The Cassini spacecraft studied the plumes released by Saturn’s moon Enceladus‚ and scientists discovered interesting molecules‚ including hydrogen cyanide‚ which is believed to be key to the formation of amino acids needed to create proteins‚ the main components of life. The study was published in Nature Astronomy. Scientists analyzed the chemical composition of the plumes and concluded that Enceladus may have more chemical energy than previously thought. This is due to the formation of molecules associated with oxidation‚ that is‚ a large amount of chemical energy is released. JPL’s Kevin Hand emphasized that Enceladus’ chemically-energized ocean could support life that could potentially use that energy to sustain itself. “The discovery of hydrogen cyanide was especially exciting because it is the starting point for most theories about the origin of life‚” said lead author John Peter of Harvard University‚ formerly of NASA (JPL). “The more we tried to address gaps in our results by testing alternative models‚ the stronger the evidence became. Eventually‚ it became clear that there was no way to correlate the composition of the plume without including hydrogen cyanide.” Enceladus is the sixth-largest moon of Saturn. It is about 500 kilometers (310 mi) in diameter‚ about a tenth of that of Saturn’s largest moon‚ Titan. The conditions created on Enceladus provide an opportunity to test in the laboratory the accuracy of the conditions under which the detected molecules are formed and to evaluate their role in the search for life. If the study results are confirmed‚ it could mean that Enceladus not only meets the basic requirements for habitability‚ but also offers favorable conditions for the emergence and maintenance of life. “Our work provides further evidence that Enceladus contains some of the most important molecules for both creating the building blocks of life and maintaining that life through metabolic reactions‚” Peter said. “Not only does Enceladus appear to meet the basic requirements for habitability‚ but we now have an idea of ​​how complex biomolecules might be formed there and what chemical processes might be involved.” The post The ocean on Enceladus may hide alien life appeared first on Anomalien.com.

If you’re looking to scratch that Dungeons &; Dragons RPG itch after Baldur’s Gate 3‚ Steam has a real treat for you this weekend. Pathfinder: Wrath of the Righteous comes from Owlcat Games‚ who you might recognize as the team behind the recently released Warhammer 40k Rogue Trader‚ and it builds a narrative-driven adventure around the Pathfinder rule set made as a spinoff from DnD. If you’re looking for something to follow up BG3‚ it might be just the ticket - and you can find out for yourself‚ as it’s a free game for the weekend‚ and cheap in a Steam sale if you enjoy yourself. Continue reading After Baldur’s Gate 3‚ another top DnD RPG is a free game this weekend MORE FROM PCGAMESN: Pathfinder classes

Writing about Shadow Gambit: The Cursed Crew always fills my heart with a mix of warmth and sadness. The tactical RPG is one of 2023’s best strategy games‚ a culmination of the formula honed by indie developer Mimimi Games through its previous games Shadow Tactics and Desperados 3. However‚ it also marks the studio’s final release‚ as it steps away from development after 15 years. Now‚ in a final parting gift‚ the team passes the torch to its community with a free update adding mod tools to Shadow Gambit. Continue reading Fantastic 2023 Steam strategy game adds mod tools as a final thank you

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