The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent signaling and underlie several hematological malignancies from myeloproliferative neoplasms (MPN) to acute leukemia and lymphomas. JAK2 contains an active kinase domain and an inactive pseudokinase domain. Interestingly‚ pathogenic mutations mainly occur in the regulatory pseudokinase domain.

Mulberry silk is a natural protein fiber that is light‚ soft and fine in nature‚ known as the ";second skin of the human body"; and ";Queen of fibers."; China is the origin of the world';s sericulture industry.

Viruses need hosts. Whether it';s measles‚ the flu or coronavirus‚ viral pathogens cannot multiply or infect other organisms without the assistance of their hosts'; cellular infrastructure. However‚ humans are not the only ones affected by viruses: animals‚ plants and even microorganisms can all serve as hosts.

Plants are made up of very rigid cells. Much like bricks in a wall‚ this feature gives them the structural support to maintain their shape and to stand upright against gravity. However‚ just like any living organism‚ plants can be injured‚ for instance‚ by wind or animal grazing. While humans and animals have cells that move with the blood to detect and heal wounds‚ plants have to evolve a very different mechanism due to their rigidity and immobility.

Western North America seems to be experiencing more extreme weather events more frequently. From scorching droughts to torrential floods‚ the climate is changing rapidly‚ with no signs of slowing down. From 2011 to 2015‚ California and neighboring states experienced extended periods of drought‚ while 2017 saw heavy rains trigger catastrophic floods.

Scientists may one day be using a new technique to potentially pick up and record key airborne forensic DNA evidence from crime scenes wiped clean of fingerprints and other trace evidence.

The world is a cluttered‚ noisy place‚ and the ability to effectively focus is a valuable skill. For example‚ at a bustling party‚ the clatter of cutlery‚ the conversations‚ the music‚ the scratching of your shirt tag and almost everything else must fade into the background for you to focus on finding familiar faces or giving the person next to you your undivided attention.

Recent decades have witnessed rapid changes in the Arctic climate‚ with warming rates surpassing global averages by three to four times. This puzzling ";Warm Arctic‚ Cold Eurasia"; climate phenomenon has profound implications‚ sparking scientific curiosity into its underlying mechanisms.

Early in May 2023‚ a small team of marine biologists arrived in the Saudi Arabian city of Jeddah. They';d flown into the local airport from Guam‚ the United States‚ Portugal‚ Spain and Japan‚ and they';d soon rendezvous with colleagues from the King Abdullah University of Science and Technology (KAUST)‚ a research university built along the banks of the Red Sea.

An extensive CO2 monitoring network set up around the San Francisco Bay Area by an atmospheric chemist from the University of California‚ Berkeley‚ has recorded the first evidence that the adoption of electric vehicles is measurably lowering the area';s carbon emissions. The findings have been published in the journal Environmental Science &;amp; Technology.