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Novel synthesis of fluorinated molecules with potential in drug research

Novel synthesis of fluorinated molecules with potential in drug research

Carboxylic acids are one of the most important substance classes in chemistry and are a component of many drugs such as aspirin and ibuprofen. To tailor the properties of carboxylic acids, fluorine atoms can be introduced into the molecular structure. However, this requires complex, multi-step synthetic routes.

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Refining turbulent flow to scale up iPS cell-based platelet manufacturing

Refining turbulent flow to scale up iPS cell-based platelet manufacturing

In a recent effort to scale up the manufacturing of platelets using iPS cell-derived megakaryocytes, Professor Koji Eto (Department of Clinical Application) and his team of researchers, through computational simulation and biological testing, conceived new design changes for an impeller-based bioreactor for large-scale, high-quality platelet production. The study is published in Communications Engineering.

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Controlling electronics with light: Ultrafast lasers manipulate magnetite's structure

Controlling electronics with light: Ultrafast lasers manipulate magnetite's structure

Researchers at EPFL have discovered that by shining different wavelengths (colors) of light on a material called magnetite, they can change its state, e.g., making it more or less conducive to electricity. The discovery could lead to new ways of designing new materials for electronics such as memory storage, sensors, and other devices that rely on fast and efficient material responses.

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Membrane protein analogs could accelerate drug discovery

Membrane protein analogs could accelerate drug discovery

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior. But because these proteins are embedded in the lipid-containing outer layer of cells, they are tricky to access and insoluble in water-based solutions (hydrophobic), making them difficult to study.

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Transforming drug discovery with AI: New program transforms 3D information into data that typical models can use

Transforming drug discovery with AI: New program transforms 3D information into data that typical models can use

A new AI-powered program will allow researchers to level up their drug discovery efforts.

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Beyond CRISPR: seekRNA delivers a new pathway for accurate gene editing

Beyond CRISPR: seekRNA delivers a new pathway for accurate gene editing

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than the industry standard, CRISPR, which has revolutionized genetic engineering in medicine, agriculture and biotechnology.

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A black hole of inexplicable mass: JWST observations reveal a mature quasar at cosmic dawn

A black hole of inexplicable mass: JWST observations reveal a mature quasar at cosmic dawn

The James Webb Space Telescope observed a galaxy in a particularly young stage of the universe. Looking back into the past, it became clear that the light from the galaxy called J1120+0641 took almost as long to reach Earth as the universe has taken to develop to the present day. It is inexplicable how the black hole at its center could have weighed over a billion solar masses back then, as independent measurements have shown. The findings are published in the journal Nature Astronomy.

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Stacking three layers of graphene with a twist speeds up electrochemical reactions

Stacking three layers of graphene with a twist speeds up electrochemical reactions

Tri-layer may be better than bi-layer for manufacturing, improving the speed and capacity of electrochemical and electrocatalytic devices.

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Many more bacteria produce greenhouse gases than previously thought, study finds

Many more bacteria produce greenhouse gases than previously thought, study finds

Caltech researchers have discovered a new class of enzymes that enable a myriad of bacteria to "breathe" nitrate when in low-oxygen conditions. While this is an evolutionary advantage for bacterial survival, the process produces the greenhouse gas nitrous oxide (N2O) as a byproduct, the third-most potent greenhouse gas, after carbon dioxide and methane.

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New AI-driven tool improves root image segmentation

New AI-driven tool improves root image segmentation

In a world striving for sustainability, understanding the hidden half of a living plant—the roots—is crucial. Roots are not just an anchor; they are a dynamic interface between the plant and soil, critical for water uptake, nutrient absorption, and, ultimately, the survival of the plant.

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